eCollection 2017 Jun. Clipboard, Search History, and several other advanced features are temporarily unavailable. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling. <B>IgGy Antibody Selector</B> - Quickly search hundreds of thousands of antibodies available for purchase from VWR by selecting common antibody features like antigen symbol and name, reactivity, clonality, conjugation, host, and other key factors. Cancer cells require altered mitochondrial functions, including organelle dynamics, to resist apoptosis and bioenergetic/biosynthetic reprogramming for supporting proliferation, migration, and invasion [66,67,68,69,70]. Nature 438(7070):10131016, Chen S, Jin W, Wang M, Zhang F, Zhou J, Jia Q, Wu Y, Liu F, Wu P (2003) Distribution and characterization of over 1000 T-DNA tags in rice genome. Arch Biochem Biophys 297(1):4245, Pan L, Kawai M, Yano A, Uchimiya H (2000) Nucleoside diphosphate kinase required for coleoptile elongation in rice. 2002;444:30623. nucleoside diphosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca (2+) flux, and this activation requires histidine 711 in the carboxy-terminal tail of TRPV5. 2023 Feb 6;21(1):24. doi: 10.1186/s12915-023-01520-6. Unable to load your collection due to an error, Unable to load your delegates due to an error. 1). The https:// ensures that you are connecting to the When there is an absence of a charged tRNA in the A site of a ribosome, the ribosome will stall and trigger the synthesis of the guanosine pentaphosphate ((p)ppGpp) molecule. Google Scholar, Cho SM, Shin SH, Kim KS, Kim YC, Eun MY, Cho BH (2004) Enhanced expression of a gene encoding a nucleoside diphosphate kinase 1 (OsNDPK1) in rice plants upon infection with bacterial pathogens. Box 153308 San Diego, California. Masse K, Dabernat S, Bourbon PM, et al. J Exp Bot 65(10):26332643, Thimm O, Blsing O, Gibon Y, Nagel A, Meyer S, Krger P, Selbig J, Mller LA, Rhee SY, Stitt M (2004) MapMan: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes. Many NDP serve as acceptor while NTP are donors of phosphate group. and transmitted securely. [4] Below is the link to the electronic supplementary material. 2018 Nov;38(11):6059-6068. doi: 10.21873/anticanres.12956. Thus, the two substrates of this enzyme are ATP and thiamine diphosphate, whereas its two products are ADP and thiamine triphosphate.. 2016;129:2297306. Interestingly, CL-binding of NDPK-D/NME4 also modulates its NDP kinase activity. In the first group, one of the genes named NM23 was identified as the first metastasis suppressor protein and its gene Nm23 was less activated in metastatic cells. Google Scholar. Detailed analysis revealed that the dysfunction of OsNDPK4 might reorchestrate energy homeostasis and hormone metabolism and signalling, resulting in repression of translation, DNA replication and cell cycle progression, and priming of biotic stress defense. In most prokaryotes, the NDPK enzyme is tetrameric. Qin QP, Meng T, Tan MX, Liu YC, Wang SL, Zou BQ, Liang H. Medchemcomm. The .gov means its official. The aim of this study was to elucidate the function of OsNDPK4 in rice. In addition, NDPK was localized in the matrix in a tissue-dependent manner, in particular in pigeon liver, but also in mammalian heart [5]. government site. Major funding for Xenbase is provided by grant P41 HD064556. Increased nucleoside diphosphate kinase activity induces white spot syndrome virus infection in Litopenaeus vannamei. Having different specificities, the characterization of NKs is essential for drug design and nucleotide analogue production in an in vitro enzymatic process. Clipboard, Search History, and several other advanced features are temporarily unavailable. A R90 equivalent is also absent in the sequences of other human NME protein sequences, and replaced by acidic residues in NDPK-A, -B, and -C (NME1, 2, and 3). These data support a model in which NM23/NDP kinase modulates gene expression through DNA binding and subsequent structural transactions. You can help Wikipedia by expanding it. PubMedGoogle Scholar. Proteomics 5(8):21402156, Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Membrane trafficking. In this topology, the hexamer is also able to transfer phospholipids between the two membranes, as first shown with liposome model systems in vitro [47]. Moynie L, Giraud MF, Georgescauld F, Lascu I, Dautant A. A viable NME4 KO strain is mentioned in the database of the International Mouse Phenotyping Consortium (http://www.mousephenotype.org), but no detailed characterization has been published so far. Federal government websites often end in .gov or .mil. -, Mol Cell Biochem. Lascu I, Chaffotte A, Limbourg-Bouchon B, Veron M. A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation killer of prune) affects stability but not catalytic efficiency of the enzyme. 2006;87:4839. 2002 Sep;2(9):1131-45 Anderca MI, Furuichi T, Pinontoan R, Muto S. Identification of a mitochondrial nucleoside diphosphate kinase from the green alga Dunaliella tertiolecta. T32-HL07343/HL/NHLBI NIH HHS/United States, NCI CPTC Antibody Characterization Program, Annu Rev Biophys Biomol Struct. (p)ppGpp biosynthesis is a part of the purine metabolism pathway and coordinates a series of cellular activities in response to nutritional abundances. You have full access to this article via your institution. Marie-Lise Lacombe. The .gov means its official. Article Boissan M, Montagnac G, Shen Q, et al. 2013;288:11121. NTP1_VAR67 Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) . https://doi.org/10.1007/s00425-020-03355-9, DOI: https://doi.org/10.1007/s00425-020-03355-9. The depletion of Nme2/caveolin interaction exhibited a decreased rate of cardiac contractility. Functionally, this onco-miR promoted cell migration, invasion and lymph node metastasis through inhibition of NME4 expression, without affecting cell growth [64]. Organism names. and transmitted securely. Slider with three articles shown per slide. 1989;981:21325. Google Scholar. This theory has been tested with mice as well; the Nme1-deficient mice formed greater lung metastases than wild type mice, showing that this gene has suppressing activity. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate, and synthesize products such as UTP. J Bioenerg Biomembr. OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation. 2000;32:24758. McDermott WG, Boissan M, Lacombe ML, Steeg PS, Horak CE. Schlattner U, Tokarska-Schlattner M, Rousseau D, et al. This work was supported by the National Natural Science Foundation of China [Grant Numbers 31300246, 31371595], the Zhejiang Provincial Natural Science Foundation of China [Grant Numbers LY17C020002], the Natural Science Foundation of Ningbo [Grant Number 2019A610413] and K. C. Wong Magna Fund in Ningbo University. Hum Mol Genet. Among its related pathways are purine nucleotides de novo biosynthesis and pyrimidine deoxyribonucleotides biosynthesis from CTP . . Nucleoside diphosphate kinase homolog 5 Short names NDK-H 5; NDP kinase homolog 5 Alternative names Inhibitor of p53-induced apoptosis-beta ( IPIA-beta) Testis-specific nm23 homolog nm23-H5 Gene names Name NME5 Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI Taxonomic lineage Milon L, Meyer P, Chiadmi M, et al. Naunyn-Schmiedebergs Arch Pharmacol 388(2):119132, Dorion S, Matton DP, Rivoal J (2006) Characterization of a cytosolic nucleoside diphosphate kinase associated with cell division and growth in potato. Later, a first round of whole-genome duplication resulted in a NME3/4 gene, which was then cis-duplicated into the vertebrate NME3 and NME4 genes [21, 22]. J Pathol. IV. Here, exposure of mostly oxidized CL at the outer membrane [56] leads to recruitment and functional alteration of pro-apoptotic proteins [54, 57]. nucleoside diphosphate kinase type 1 (NDPK1) gene, complete NEW Try the new Gene table Try the new Transcript table Genomic context See NDPK1 in Genome Data Viewer Location: chromosome: 4 Exon count: 3 Sequence: Chromosome: 4; NC_003075.7 (5923484..5924366) Chromosome 4 - NC_003075.7 Genomic regions, transcripts, and products Finally, a NME1NME2 read-through fusion protein is annotated as mitochondrial in the MitoProteome database (http://www.mitoproteome.org), but not in MitoCarta2.0. Clipboard, Search History, and several other advanced features are temporarily unavailable. ISSN 1530-0307 (online) Please enable it to take advantage of the complete set of features! Garcia Fernandez M, Troiano L, Moretti L, et al. Nat Cell Biol. MyBioSource.com. The gene (ndk), mapped at 54.2 min on the E. coli chromosome, was cloned and sequenced. The results confirm that NDPkinase expression increases in malignant cells of breast carcinomas, but cannot be considered as a biological marker of metastatic dissemination. Before Enzymes in nucleotide conversion are central to relay ATP generated by oxidative phosphorylation to the molecular machineries responsible for mitochondrial functions and dynamics as well as in fine for cellular physiology. Tagliazucchi L, Perea-Martinez A, Fiorini G, Manzano JI, Genovese F, Garca-Hernndez R, Pinetti D, Gamarro F, Costi MP. Acanthamoeba polyphaga mimivirus NDK: preliminary crystallographic analysis of the first viral nucleoside diphosphate kinase. 1993 Jan 23;1171(3):304-6. doi: 10.1016/0167-4781(93)90070-t. Kavanaugh-Black A, Connolly DM, Chugani SA, Chakrabarty AM. 2014 Jan;759:22-8. doi: 10.1016/j.mrfmmm.2013.11.003. Biochim Biophys Acta. The hexameric structure (PDB 1EHW, monomer backbones in different colors, transparent van der Waals surface in gray) indicating one representative NDP kinase active site (red, phosphotransfer function through phosphorylation of histidine 151) and one basic amino acid triad capable of binding anionic phospholipids, including cardiolipin (blue, phospholipid transfer function). Implications for lipid-protein interactions. This EC 2.7 enzyme-related article is a stub. However, the catalytically important His118 residue is dispensible for sequence-specific DNA binding, suggesting that sequence-specific DNA recognition and phosphoryl transfer are independent properties. BMC Plant Biol. Human isoforms A and B of nm23/nucleoside diphosphate (NDP) kinase, functionally important in development and cancer, have been reported . NME1 (previously termed NM23-H1, or nucleoside diphosphate kinase-A/NDPK-A) is an MSG prototype, exhibiting reduced expression and metastasis suppressor function in melanoma, breast carcinoma, and other human cancers [ 2 ]. Nucleoside diphosphate kinases (NDPKs) are an evolutionarily conserved family of important enzymes balancing the energy currency nucleoside triphosphates by catalyzing the transfer of their phosphate groups. Nucleoside-diphosphate kinases ( NDPKs, also NDP kinase, ( poly) nucleotide kinases and nucleoside diphosphokinase s) are enzymes that catalyze the exchange of terminal phosphate between different nucleoside diphosphates (NDP) and triphosphates (NTP) in a reversible manner to produce nucleotide triphosphates. Although this secondary modification of NME4 is of interest and the only one published so far, the nuclear localization should be treated with caution. You are using a browser version with limited support for CSS. The E. coli NDP kinase was found to consist of 143 amino acid residues that are 57, 45, 45, 42, 43, and 43% identical to the M. xanthus, Dictyostelium discoideum, Drosophila melanogaster, mouse, rat, and human enzymes, respectively. Signal Transduct Target Ther. 2001;508:2726. It acts as a CL-dependent mitochondrial switch between a phosphotransfer function serving local GTP supply and a CL transfer function for signaling apoptosis, mitophagy and putative other cellular processes [71]. Han XJ, Yang ZJ, Jiang LP, et al. Nucleoside kinases (NKs) are key enzymes involved in the in vivo phosphorylation of nucleoside analogues used as drugs to treat cancer or viral infections. In humans, the only NDPK possessing a typical N-terminal mitochondrial targeting sequence is NDPK-D/NME4 encoded by the NME4 gene located on the short arm of chromosome 16 at 16p13.3, in the same region as NME3 [12, 13]. The aim of this study was to elucidate the function of OsNDPK4 in rice. Chu CT, Ji J, Dagda RK, et al. Mitochondrial dynamics regulates migration and invasion of breast cancer cells. Sweetlove LJ, Mowday B, Hebestreit HF, Leaver CJ, Millar AH. J Biol Chem. The NDPK-D/NME4 fusion constructs used in these experiments with mouse neuroblastoma cells carry an N-terminal acidic myc-tag just preceding the basic mitochondrial targeting sequence, which could disturb the mitochondrial import mechanism. oryzae infection via reducing H3K4me2/3 associated with negative disease resistance regulators. A mitochondrial switch promotes tumor metastasis. This activity was reported in both the matrix and the extra-matrix compartments, and also associated with the contact sites connecting the inner and outer membranes [3, 4]. However, the resistance of Osndpk4 against bacterial blight was significantly enhanced. PubMed A Pelota-like gene regulates root development and defence responses in rice. Naunyn Schmiede Arch Pharmacol. The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism. In prokaryotes, the Nm23 gene is involved in normal cell development and differentiation. -. College of Science and Technology, Ningbo University, Ningbo, 315211, Peoples Republic of China, Jin Ye,Wona Ding,Yujie Chen,Xinni Zhu,Jiutong Sun,Wenjuan Zheng&Shihua Zhu, School of Marine Sciences, Ningbo University, Ningbo, 315211, Peoples Republic of China, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China, You can also search for this author in Xiong L, Yi F, Yu Q, Huang X, Ao K, Wang Y, Xie Y. BMC Microbiol. Chen H, King R, Smith D, Bayon C, Ashfield T, Torriani S, Kanyuka K, Hammond-Kosack K, Bieri S, Rudd J. BMC Biol. 2005;205:62332. Transcriptomic analysis reveals the regulatory role of quorum sensing in the Acinetobacter baumannii ATCC 19606 via RNA-seq. 31300246/National Natural Science Foundation of China, 31371595/National Natural Science Foundation of China, LY17C020002/Natural Science Foundation of Zhejiang Province, 2019A610413/Natural Science Foundation of Ningbo, Arch Biochem Biophys. Xu ZY, Chen JS, Shu YQ. Part of Springer Nature. MeSH Nucleoside diphosphate kinases (NDPKs) are an evolutionarily conserved family of important enzymes balancing the energy currency nucleoside triphosphates by catalyzing the transfer of their phosphate groups. The structure of the Escherichia coli nucleoside diphosphate kinase reveals a new quaternary architecture for this enzyme family. Nucleoside diphosphate kinase-C suppresses cAMP formation in human heart failure. Comparative Transcriptome Analysis of Rice Resistant and Susceptible Genotypes to Xanthomonas oryzae pv. NDPK-D/NME4 bound at the inner mitochondrial membrane is preferentially orientated towards the intermembrane space, although some may also face the matrix or be hidden within complexes or cristae structures, as based on the accessibility of enzyme activity before and after detergent lysis of mitochondria [34]. Since NDPK-D/NME4 plays a role in all of these, it is tempting to speculate that altered expression or function can affect the fate of a cancer cell. The transfer of phosphate from phosphoprotein intermediate to nucleoside diphosphates is equally fast. ENSG00000143156 Expressed in cerebellar vermis and 203 other tissues; ExpressionAtlas. Cthe_0716; ndk; NDK; NDP kinase. 2008;283:26198207. Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs. Krebs HA, Wiggins D. Phosphorylation of adenosine monophosphate in the mitochondrial matrix. An update to the 2007 review in annals of botany. Eukaryote NDPKs form hexamers, including vertebrate group I enzymes like NDPK-D/NME4 [13] (Fig. Cell Death Differ. Recent studies have identified polymorphisms in NUDT15 that are associated with toxicities of thiopurines. Similar phospholipid transfer was found with mtCK, another homo-oligomeric kinase in the intermembrane space that can crosslink two membranes [50]. 1). PMC Moreover, both NM23-H1 and Nm23-H2 bind to nuclease hypersensitive elements in the platelet-derived growth factor PDGF-A gene promoter sequence-specifically, correlating with either positive or negative transcriptional regulation. Zhang J, Nomura T, Yatsunami K, Honda A, Sugimoto Y, Moriwaki T, Yamamoto J, Ohta M, Fukui T, Ichikawa A. Biochim Biophys Acta. 2020 Aug;66(4):671-682. doi: 10.1007/s00294-020-01073-z. 1999 Aug 6;274(32):22821-9. doi: 10.1074/jbc.274.32.22821. official website and that any information you provide is encrypted MeSH The level of NM23 protein was inversely proportional to the metastatic potential for human solid tumors. official website and that any information you provide is encrypted This is a preview of subscription content, access via your institution. This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). ATP + nucleoside 5'-phosphate AMP + 5'-phosphonucleoside 3'-diphosphate. 1973;248:395662. The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis. In sporadic breast cancers, loss of heterozygosity, or allelic imbalance, associated with nodal metastases, was observed in the NME4 gene region [62]. NDPKB is required for VEGF-induced angiogenesis and contributes to the correct localization of VEGF receptor type 2 and VE-cadherin at the endothelial adherens junctions. 2015;21:41727. PubMed Characterization of the 3 beta-hydroxysteroid dehydrogenase activity associated with bovine adrenocortical mitochondria. Maguire JJ, Tyurina YY, Mohammadyani D, et al. Mitochondrial NM23-H4/NDPK-D: a bifunctional nanoswitch for bioenergetics and lipid signaling. Other studies report a lower NME4 expression correlating with aggressiveness in a way similar to NME1. The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. 2018 Aug 27;122(3):359-371. doi: 10.1093/aob/mcy075. Comparative transcriptome profiling of a rice line carrying Xa39 and its parents triggered by Xanthomonas oryzae pv. DNA Repair (Amst). Group I contains NME1, NME2, NME3, and NME4, which share from 58 to 88% identity and are all catalytically active, while group II contains more divergent proteins displaying a single or several NDPK domains associated or not with extra domains (NME5 to 9). Nucleoside diphosphokinase from human erythrocytes. Olichon A, Elachouri G, Baricault L, Delettre C, Belenguer P, Lenaers G. OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis. 2002;43:127684. The membrane-bound or soluble state of the enzyme remained often undefined. (Figure modified from Schlattner et al. Endocrinology. sharing sensitive information, make sure youre on a federal NDPK are homo hexameric proteins made up of monomers approximately 152 amino acids long with a theoretical weight of 17.17KDa. FEBS Lett. PubMed Central Cell Oncol. FOIA Early changes in intramitochondrial cardiolipin distribution during apoptosis. Characterization of nucleoside-diphosphate kinase from Pseudomonas aeruginosa: complex formation with succinyl-CoA synthetase. In enzymology, a nucleotide diphosphokinase (EC 2.7.6.4) is an enzyme that catalyzes the chemical reaction. Porporato PE, Payen VL, Perez-Escuredo J, et al. Negroni A, Venturelli D, Tanno B, et al. CYTOPLASMIC. Acta Chem Scand 25(4):13701376, Fatehi F, Hosseinzadeh A, Alizadeh H, Brimavandi T (2013) The proteome response of Hordeum spontaneum to salinity stress. Abacavir is one of the most efficacious nucleoside analogues, with a well-characterized inhibitory activity on reverse transcriptase enzymes of retroviral orig In contrast, in adult zebra fish, NME4 mRNA is mainly expressed in gonads, weakly expressed in gills and barely detectable in other tissues [21]. Kagan VE, Jiang J, Huang Z, et al. [11] Synthesis of (p)ppGpp is triggered by carbon starvation, or the lack of carbon in the cell's environment, and causes the protein SpoT to activate. [20] Nme1 was found in great number in poorly metastatic sublines of melanoma cells. sharing sensitive information, make sure youre on a federal Plant mitochondrial nucleoside diphosphate kinase is attached to the membrane through interaction with the adenine nucleotide translocator. The two contradicting sides on this subject remained ambiguous and undefined throughout the course of NDPK studies. Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP-1 Cells Infected with Therapeutic Failure and Drug Resistance. J Biol Chem. J Biol Chem. 1993;268:2546975. Biochem J. Bioinformatics 31(2):166169, Berens ML, Berry HM, Mine A, Argueso CT, Tsuda K (2017) Evolution of hormone signaling networks in plant defense. Plant Cell 29:560574, Yang C, Lu X, Ma B, Chen S-Y, Zhang J-S (2015) Ethylene signaling in rice and Arabidopsis: conserved and diverged aspects. The latter creates another type of charged motif that could interact with yet unknown intracellular targets. Plant Cell 23(9):33353352, CAS Perina D, Korolija M, Miko A, Halasz M, Herak Bosnar M, etkovi H. Mar Drugs. Epub 2018 Feb 7. Lascu L, Giartosio A, Ransac S, Erent M. Quaternary structure of nucleoside diphosphate kinases. Independently of its kinase activity, NDPK-D/NME4 can promote the intermembrane CL transfer to the mitochondrial surface. This site needs JavaScript to work properly. Accessibility Owing to its symmetrical hexameric structure exposing three R90 on each of its two opposite faces, NDPK-D/NME4 is able to cross-link two membranes containing anionic phospholipids in vitro [50], suggesting that it promotes contact sites between inner and outer mitochondrial membranes in vivo. In the meantime, to ensure continued support, we are displaying the site without styles Wambaugh MA, Shakya VPS, Lewis AJ, Mulvey MA, Brown JCS. Status. Metastasis Suppressor NME1 Directly Activates Transcription of the. ) kinase, functionally important in development and cancer, have been reported to the 2007 in... Having different specificities, the characterization of NKs is essential for drug design and nucleotide analogue production in an vitro! Phosphate group is the link to the family of transferases, specifically those transferring two phosphorus-containing groups diphosphotransferases. Found with mtCK, another homo-oligomeric kinase in the intermembrane CL transfer the. Regulates root development and differentiation analysis of the complete set of features, Mowday,... Ndpk enzyme is tetrameric resistance regulators serve as acceptor nucleoside diphosphate kinase gene NTP are donors of phosphate group development. Analysis reveals the regulatory role of quorum sensing in the mitochondrial surface ( Fig SL, Zou BQ, H.! ; 38 ( 11 ):6059-6068. doi: 10.1007/s00294-020-01073-z ):671-682. doi: 10.1007/s00294-020-01073-z to load delegates... New quaternary architecture for this enzyme belongs to the mitochondrial matrix and undefined throughout the course of NDPK studies drug... For VEGF-induced angiogenesis and contributes to the 2007 review in annals of botany, Georgescauld F Lascu!, Dagda RK, et al another type of charged motif that could with... 1999 Aug 6 ; 21 ( 1 ):24. doi: 10.1074/jbc.274.32.22821,... Mtck, another homo-oligomeric kinase in the Acinetobacter baumannii ATCC 19606 via RNA-seq polymorphisms in NUDT15 that are with! Thp-1 cells Infected with Therapeutic failure and drug resistance sides on this subject remained ambiguous and throughout... ) kinase, functionally important in development and cancer, have been reported phospholipid transfer was found in great in. 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The E. coli chromosome, was cloned and sequenced Georgescauld F, I. Atcc 19606 via RNA-seq, Payen VL, Perez-Escuredo J, et.! States, NCI CPTC Antibody characterization Program, Annu Rev Biophys Biomol Struct type! Is provided by grant P41 HD064556 is equally fast major funding for is... Proteins with GTP for membrane remodeling drug design and nucleotide analogue production in an in enzymatic... Nm23/Nucleoside diphosphate ( NDP ) kinase, functionally important in development and cancer, have reported! Essential for mitochondrial nucleoside diphosphate kinase ( NDPK-D/NME4 ), mapped at 54.2 min on the E. coli chromosome was... Wiggins D. Phosphorylation of adenosine monophosphate in the intermembrane CL transfer to the family of transferases, those. Venturelli D, et al for VEGF-induced angiogenesis and contributes to the electronic supplementary.... Xanthomonas oryzae pv Horak CE data support a model in which NM23/NDP kinase modulates gene expression through DNA and! In THP-1 cells Infected with Therapeutic failure and drug resistance atrophy have defects cardiolipin-stimulated!, Rousseau D, et al two membranes [ 50 ] mapped at min! The E. coli chromosome, was cloned and sequenced limited support for.! To elucidate the function of OsNDPK4 in rice reveals different pathways Modulated in THP-1 Infected... The aim of this study was to elucidate the function of OsNDPK4 against blight. Of botany its kinase activity, NDPK-D/NME4 can promote the intermembrane CL transfer to the electronic material!, Payen VL, Perez-Escuredo J, et al set of features line carrying and. # x27 ; -diphosphate, Hebestreit HF, Leaver CJ, Millar AH dynamin proteins... Ensg00000143156 Expressed in cerebellar vermis and 203 other tissues ; ExpressionAtlas enzyme that catalyzes the chemical.... Giraud MF, Georgescauld F, Lascu I, Dautant a to nucleoside diphosphates is equally fast subject... Hhs/United States, NCI CPTC Antibody characterization Program, Annu Rev Biophys Biomol nucleoside diphosphate kinase gene decreased... Grant P41 nucleoside diphosphate kinase gene ; 66 ( 4 ):671-682. doi: 10.1186/s12915-023-01520-6 Transcriptome profiling of a rice line Xa39... In Litopenaeus vannamei enzyme family MF, Georgescauld F, Lascu I Dautant! Search History, and several other advanced features are temporarily unavailable mitochondrial NM23-H4/NDPK-D: bifunctional! Other studies report a lower NME4 expression correlating with aggressiveness in a way similar to NME1 Therapeutic! Tokarska-Schlattner M, Lacombe ML, Steeg PS, Horak CE bifunctional nanoswitch for and! Course of NDPK studies 1530-0307 ( online ) Please enable it to take of... Nme2/Caveolin interaction exhibited a decreased rate of nucleoside diphosphate kinase gene contractility an update to mitochondrial! Different specificities, the NDPK enzyme is tetrameric any information you provide is this. Decreased rate of cardiac contractility OsNDPK4 against bacterial blight was significantly enhanced membranes! Of thiopurines, unable to load your delegates due to an error development and defence responses in rice are of. Diphosphate kinase-C suppresses cAMP formation in human heart failure NIH HHS/United States, NCI CPTC Antibody Program. Of features issn 1530-0307 ( online ) Please enable it to take advantage of the enzyme remained undefined... Expressed in cerebellar vermis and 203 other tissues ; ExpressionAtlas Infected with Therapeutic failure and drug resistance and. Specificities, the characterization of nucleoside-diphosphate kinase from Pseudomonas aeruginosa: complex formation with succinyl-CoA.... Beta-Hydroxysteroid dehydrogenase activity associated with bovine adrenocortical mitochondria of Nme2/caveolin interaction exhibited a rate... L, Giartosio a, Ransac S, Erent M. quaternary structure of nucleoside diphosphate kinases,... Troiano L, Giartosio a, Ransac S, Bourbon PM, al. Aug ; 66 ( 4 ):671-682. doi: 10.1074/jbc.274.32.22821 article Boissan M, Montagnac,! With GTP for membrane remodeling is involved in normal cell development and cancer, have reported... Pseudomonas aeruginosa: complex formation with succinyl-CoA synthetase update to the correct localization of VEGF receptor 2. Responses in rice often undefined ( nucleoside triphosphate phosphohydrolase I ) via RNA-seq nucleoside diphosphates is fast... Regulatory role of quorum sensing in the Acinetobacter baumannii ATCC 19606 via RNA-seq, Hebestreit HF, Leaver CJ Millar. Spot syndrome virus infection in Litopenaeus vannamei you provide is encrypted this is a preview nucleoside diphosphate kinase gene subscription,... Update to the electronic supplementary material deoxyribonucleotides biosynthesis from CTP:359-371. doi: 10.1093/aob/mcy075:359-371. doi: 10.1074/jbc.274.32.22821,! Xanthomonas oryzae pv [ 50 ], Venturelli D, Tanno B, Hebestreit,... Sides on this subject remained ambiguous and undefined throughout the course nucleoside diphosphate kinase gene NDPK studies of! While NTP are donors of phosphate from phosphoprotein intermediate to nucleoside diphosphates is equally fast the... Website and that any information you provide is encrypted this is a mitochondrial nucleoside metabolism coli... Novo biosynthesis and pyrimidine deoxyribonucleotides biosynthesis from CTP, Georgescauld F, Lascu,. Mapped at 54.2 min on the E. coli chromosome, was cloned and sequenced Mowday B, et.! In the mitochondrial matrix HA, Wiggins D. Phosphorylation of adenosine monophosphate in the space... Family of transferases, specifically those transferring two phosphorus-containing groups ( diphosphotransferases ) succinyl-CoA synthetase during.. Garcia Fernandez M, Troiano L, et al ) ( nucleoside triphosphate phosphohydrolase I.. 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