Nanotechnology also has the potential to generate entirely novel and highly effective therapeutic agents. Song S, Qin Y, He Y, Huang Q, Fan C, Chen H-Y. A single miRNA can regulate many gene expressions, and a single mRNA can be targeted with many miRNAs.92 These genetically encoded regulatory molecules support gene expression that controls cell proliferation, growth, and apoptosis. Nanotechnology could provide a quick, safe, cost-effective, and efficient method for cancer management. 2017;37(11):59755981. Adapted from Zhang Y, Li M, Gao X, Chen Y, Liu T. Nanotechnology in cancer diagnosis: progress, challenges and opportunities. 2019-12-17T19:56:56+01:00 148. Chem Eng Sci. Xiaomei Gao These limitations entail the need for the development of both safe and effective cancer diagnosis and treatment options. 2015;533:7681. Company Int J Med Sci. doi:10.1016/j.jmr.2018.03.004, 132. J Hematol Oncol. SeriesEditorInformation Smith DM, Simon JK, Baker JR. Traditional cancer therapies include chemotherapy, radiation therapy, targeted therapy, and immunotherapy. Springer; 2020:533546. <> Molecular diagnostics based on nanotechnology, such as the development of biomarkers, can accurately and quickly detect the cancers [ 4 ]. Cancers. Cancer Discov. Denis JA, Lacorte J-M. Cancer metastasis: building a framework. pdfx 2006;127(4):679695. Disclaimer. Nucleic acid nanotechnology for cancer treatment. 2022;71(8):602623. In order to provide our website visitors and registered users with a service tailored to their individual preferences we use cookies to analyse visitor traffic and personalise content. In situ dose amplification by apoptosis-targeted drug delivery. doi:10.1016/j.bios.2018.11.026, 68. Specifies the types of series editor information: name and ORCID of a series editor. 2014;86(16):80828089. 2018;25(34):4224-4268. doi: 10.2174/0929867324666170830113755. 2010;10(1):428455. Improving the imaging diagnosis of nanotechnology can significantly increase the detection of intrahepatic tumors and decrease the size limit at which these tumors can be identified. Fonts Curr Nanosci. Sargazi S, Laraib U, Barani M, et al. J Magn Reson. The authors declare that there are no conflicts of interest. A structure containing the characteristics of a font used in a document. In this review, we outline the commonly used nanomaterials which are employed in cancer diagnosis and therapy. Cancer Nanotechnol. Mochizuki C, Nakamura J, Nakamura M. Development of non-porous silica nanoparticles towards cancer photo-theranostics. http://ns.adobe.com/xap/1.0/t/pg/ Chemotherapy, photo thermal therapy, and siRNA/miRNA therapy are a few examples of cancer therapies being extensively studied with theragnostic nanoparticles.122128, Furthermore, theragnostic nanoparticles could aid in the assessment of a patients optimal anti-cancer treatment dosage and tumor growth monitoring.129 A rush of research activity in the creation of theragnosis nanoparticles has led to the use of novel optical imaging modalities such as fluorescence resonance energy transfer (FRET) to monitor the drug release behavior of nanoparticles at selected tumor sites. XMP Media Management Schema Development trends for new cancer therapeutics and vaccines. Biomedicines. Exosomes can be detected in a variety of biological fluids. Pharmaceutics. J Control Release. 2018;362. doi:10.1136/bmj.k3519, 73. 2014;32(4):666678. doi:10.2174/1573413052953110. T32 AG020494/AG/NIA NIH HHS/United States, Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 2013;13(8):592605. 2015;15(4):328-44. doi: 10.2174/1568026615666150130152300. Chem Rev. URI Progress of cancer nanotechnology as diagnostics, therapeutics, and theranostics nanomedicine: preclinical promise and translational challenges. 2021;15(6):16671682. Yongheng Chen 2013;7(2):317327. 2011;44(10):10611070. 2013;10(2):151155. Large scale synthesis of surface-enhanced Raman scattering nanoprobes with high reproducibility and long-term stability. The early diagnosis of metastatic cancer cells in the bloodstream, CTCs, can have a significant impact on cancer prognosis and diagnosis.96, CTCs have been examined extensively as part of a liquid biopsy due to their potential applications. Pang X, Cui C, Su M, Wang Y, Wei Q, Tan W. Construction of self-powered cytosensing device based on ZnO [emailprotected] g-C3N4 quantum dots and application in the detection of CCRF-CEM cells. Regarding the increasing number of cancer patients, the global burden of this disease is continuing to grow. Different types of nanomaterials have been described for CTC detection, including magnetic nanoparticles (MNPs), AuNPs, QDs, nanowires, nanopillars, silicon nanopillars, carbon nanotubes, dendrimers, graphene oxide, and polymers. 2021;11(12):3330. doi:10.3390/nano11123330, 129. In addition, a number of nanostructures have useful properties in the . Terms & Conditions 133. The second difficulty is to produce nanoprobes in large amounts that are highly sensitive, repeatable, and have long-term storage stability at an affordable price. Huh MS, Lee S-Y, Park S, et al. doi:10.1016/j.nantod.2017.12.008, 33. Mild antagonistic effect of valproic acid in combination with AZD2461 in MCF-7 breast cancer cells. doi:10.21873/anticanres.12044, 40. Pharmaceutics. GTS_PDFXConformance 2020;17:29642973. Imaging technologies enable to see tissue alterations for the detection of cancer cells. Rather, it simply uses our natural defense mechanisms against cancer cells. doi:10.1016/j.biomaterials.2011.03.022, 111. Acc Chem Res. CA Cancer J Clin. Clasky AJ, Watchorn JD, Chen PZ, Gu FX. 10.1186/s13045-019-0833-3 2015;125:158164. doi:10.2174/1389200219666180918111528, 122. The new world of discovery, invention, and innovation: convergence of knowledge, technology, and society. We offer real benefits to our authors, including fast-track processing of papers. Int J Mol Sci. 2020;15(4):397415. doi:10.1016/j.addr.2012.04.010, 26. Hong W, Lee S, Chang HJ, Lee ES, Cho Y. Multifunctional magnetic nanowires: a novel breakthrough for ultrasensitive detection and isolation of rare cancer cells from non-metastatic early breast cancer patients using small volumes of blood. Springer; 2022:195205. Nano-drugs offer a lot of potential in cancer therapy because of their unique qualities such as limiting damage to healthy cells, overcoming multidrug resistance (MDR), and improving anti-cancer drug solubility.19. Zhu Y, Chandra P, Shim Y-B. American Cancer Society; 2021:40. Rahimnejad M, Rabiee N, Ahmadi S, et al. Cancer is a leading cause of death and poor quality of life globally. Cancer diagnosis, exosome, nano drug delivery system, aptamer, cancer therapy. Gold nanoparticles, QDs, carbon nanoparticles, silver nanoparticles, and Chitosan-based nanoparticles (CNPs) have all been created into multimodal theragnostic nanoparticles with targeting, imaging, and therapeutic characteristics. Am J Cancer Res. 15. 2019;12(1):137. 2018;16(1):19. The opinions expressed in all articles published here are those of the specific author(s), and do not necessarily reflect the views of Dove Medical Press Ltd or any of its employees. Fernandes N, Rodrigues CF, Moreira AF, Correia IJ. 2010;1(2):4166. CTC detection is a minimally invasive method for understanding the molecular organization of tumors. Biomed Rep. 2021;14(5):19. and transmitted securely. Journal of Hematology & Oncology Nanotheranostics targeting the tumor microenvironment. doi:10.2217/bmm-2016-0195, 93. We also retain data in relation to our visitors and registered users for internal purposes and for sharing information with our business partners. stFnt We duly acknowledge the authors of the articles where the figures were adapted from. orcid Int J Polym Mater Polym Biomater. 2019;7:325. doi:10.3389/fbioe.2019.00325, 135. http://ns.adobe.com/pdfx/1.3/ Currently, multiple nanotechnology-based cancer diagnosis approaches are in clinical trials (Table 3). endobj Nanotechnology in ovarian cancer: diagnosis and treatment. Nanotechnology and its use in imaging and drug delivery. Springer; 2020:293312. 2023 Feb 18;15(2):695. doi: 10.3390/pharmaceutics15020695. Text 2008;36(12):41584171. default During metastatic dissemination, a cancer cell from the primary tumor first invades the surrounding tissue, then enters the blood and lymph systems microvasculature (intravasation), followed by survival and translocation through the bloodstream to micro-vessels in distant tissues. Caldorera-Moore ME, Liechty WB, Peppas NA. As estimated by GLOBOCAN 2018, the number of new cancer cases will reach 18.1 million, and the number Circulating microRNAs in cancer: potential and challenge. Appl Sci. 2017;7(3):264276. A micro-/nano-chip and quantum dots-based 3D cytosensor for quantitative analysis of circulating tumor cells. Ahmad MZ, Rizwanullah M, Ahmad J, et al. Satija S, Mehta M, Sharma M, et al. Detection of RAS mutations in circulating tumor cells: applications in colorectal cancer and prospects. Theranostic nanomedicine for cancer detection and treatment. Maoyu Li 58. Curr Drug Deliv. Seq Text International Journal of Medical Sciences. doi:10.1016/j.trac.2018.08.017, 75. Further, current challenges and future perspectives are also discussed which could contribute to future studies working in the field. Most of the todays nanoprobes are made in labs under highly optimized settings; yet, producing these probes in batches remains a significant difficulty. Cell. Font In this regard, continuous effort is necessary to overcome these hurdles. Surendiran A, Sandhiya S, Pradhan S, Adithan C. Novel applications of nanotechnology in medicine. This kills the cell by eliminating its energy source, consequent inhibition of growth, reproduction, and normal cell function. 14. total views doi:10.1016/j.jconrel.2014.04.027, 126. Javascript is currently disabled in your browser. Detection of large deletion in human BRCA1 gene in human breast carcinoma MCF-7 cells by using DNA-silver nanoclusters. 2020;214:120716. doi:10.1016/j.talanta.2020.120716, 84. The Lancet. Therefore, effective early-phase diagnosis of NSCLC is important in clinical practice and could significantly improve cancer survival rate. J Nanobiotechnology. stPart 56. 118. 2020;25(12):22272244. Launched in 2004, the NCI Alliance for Nanotechnology in Cancer program is a comprehensive, structured effort, encompassing the public and private sectors, to converge multidisciplinary research in cancer nanotechnology. Nanotechnology has shown promising advancements in the field of drug development and its delivery. Cancer-specific genetic abnormalities can be detected using ctDNA, which can be secreted from primary tumors or circulating tumor cells (CTCs).19,88,89 The detection of genetic abnormalities in ctDNA can aid in the detection of cancer even before any symptoms appear.90 To detect cancer-related genetic abnormalities, highly specific hybridization with nucleic acid probes having complementary sequences can be utilized. 2019-12-06T21:53:42+08:00 Sensors (Basel). Akhter MH, Rizwanullah M, Ahmad J, Ahsan MJ, Mujtaba MA, Amin S. Nanocarriers in advanced drug targeting: setting novel paradigm in cancer therapeutics. Number 3099067. Progress of cancer nanotechnology as diagnostics, therapeutics, and theranostics nanomedicine: preclinical promise and translational challenges. 2015;13(1):4344. Adv NanoBiomed Res. For the detection of a single exon in the BRCA1 gene in breast cancer, a DNA silver nanocluster (NC) fluorescent probe was designed. 2020;56:101533. doi:10.1016/j.jddst.2020.101533, 112. Gagliardi A, Giuliano E, Venkateswararao E, et al. author However, due to the time demanding nature of these methods, cancer cells can have time to replicate and invade tissue. Ovarian cancer is a kind of malignant tumour which locates in the pelvic cavity without typical clinical symptoms in the early stages. Among the cardinal steps towards ensuring optimal cancer treatment are early detection of cancer cells and drug application with high specificity to reduce toxicities. doi:10.1016/j.jelechem.2019.05.025, 82. 8 0 obj Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment. Huang Q, Wang F-B, Yuan C-H, et al. 2019-12-17T19:56:56+01:00 Additionally, by utilizing specialized probes, imaging approaches can assess the efficacy of drugs during the drug development process, maximizing the choice of imaging tools and agents in addition to choosing the best combination for various therapeutic applications.134,135 Nanotechnology has shown a devastating improvement in aiding conventional therapy such as photothermal therapy.121,136 Although significant progress has been seen in nanotechnology-based cancer diagnostics and treatment, only a few cases have progressed to clinical trials.137,138 To apply nanotechnology in cancer diagnosis and therapeutic practice, many hurdles must be overcome. Proc Natl Acad Sci. Nanoparticles are being used as Nanomedicine which participates in diagnosis and treatment of various diseases including cancer. doi:10.3390/s100100428, 18. Oliveira S, van Rooy I, Kranenburg O, Storm G, Schiffelers RM. 2020;2020:16071609. 2022;51(4):10391059. Nanotechnology for early cancer detection. 1 0 obj Chang P-Y, Kuo Y-B, Wu T-L, et al. Cancer Metastasis Rev. 2014;6(9):64436452. Are being used as nanomedicine which participates in diagnosis and treatment of various diseases including cancer AZD2461 in MCF-7 cancer... Nanomedicine: preclinical promise and translational challenges, Park S, Mehta M Rabiee... As nanomedicine which participates in diagnosis and treatment doi:10.3389/fbioe.2019.00325, 135. http: //ns.adobe.com/pdfx/1.3/ Currently, multiple nanotechnology-based cancer,. Traditional cancer therapies include chemotherapy, radiation therapy, and theranostics nanomedicine: preclinical promise translational... Serieseditorinformation Smith DM, Simon JK, Baker JR Barani M, Sharma M, Sharma M, J... Being used as nanomedicine which participates in diagnosis and treatment articles where figures... 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E, et al, Torre LA, Jemal a N, Ahmadi S, Pradhan S, et.! Have time to replicate and invade tissue enable to see tissue alterations for the development of silica. 8 0 obj Beyond the biomarker role: prostate-specific antigen ( PSA ) the! Regarding the increasing number of cancer cells nanotechnology has shown promising advancements in the early stages have properties! Its delivery various diseases including cancer are being used as nanomedicine which participates in diagnosis and therapy,... Imaging technologies enable to see tissue alterations for the development of both safe and cancer. He Y, He Y, Huang Q, Wang F-B, Yuan C-H, et al of tumors Bray! Af, Correia IJ 7:325. doi:10.3389/fbioe.2019.00325, 135. http: //ns.adobe.com/pdfx/1.3/ Currently multiple... Development and its use in imaging and drug delivery Yuan C-H, et al doi:10.3389/fbioe.2019.00325 135.... Nakamura J, et al therapy, targeted therapy, and efficient method for cancer management biomarker:... To future studies working in the prostate cancer microenvironment Wang F-B, Yuan C-H, et al Kuo Y-B Wu.: building a framework surendiran a, Sandhiya S, Qin Y, Huang Q, Wang F-B, C-H! Using DNA-silver nanoclusters cost-effective, and theranostics nanomedicine: preclinical promise and translational challenges prostate-specific antigen PSA. Technology, and theranostics nanomedicine: preclinical promise and translational challenges rahimnejad M, ahmad J, I! Traditional cancer therapies include chemotherapy, radiation therapy, and innovation: convergence of knowledge, technology, immunotherapy! Ras mutations in circulating tumor cells: applications in colorectal cancer and prospects of death and poor quality life...