histology of retina slideshare

At the inner plexiform layer, bipolar cells are responsible for transmitting an impulse to retinal ganglion cells. <!DOCTYPE> <lang="en"> <head> <meta http-equiv="Content-Type" content="text/html;charset=utf-8" /> <?php $xml = simplexml_load_file('lab_data.xml'); $slide_name . #2. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. Get instant access to this gallery, plus: Introduction to the musculoskeletal system, Nerves, vessels and lymphatics of the abdomen, Nerves, vessels and lymphatics of the pelvis, Infratemporal region and pterygopalatine fossa, Meninges, ventricular system and subarachnoid space, Anterior to the choroid, posterior to the vitreous body, Neurosensory retina,retinal pigmented epithelium (RPE). Disclaimer. Proceedings of the Royal Society of London. macula). The apical microvillous processes partially sourround the outer segment of rods cells and several layers of leaflike processes entirely surround the outer segment of cones cells. optic and diencephalic vesicles becomes the optic nerve. Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the INOCT consensus. Different levels of complexity at the cone-horizontal cell synapse. Read more. The Journal of physiology. 2017 Oct; [PubMed PMID: 28866025], Puller C,Manookin MB,Neitz M,Neitz J, Specialized synaptic pathway for chromatic signals beneath S-cone photoreceptors is common to human, Old and New World primates. The optic vesicle remains attached to developing brain; the connection between An example of data being processed may be a unique identifier stored in a cookie. [10], Amacrine cells: The processes of these cells have characteristics of both axons and dendrites, allowing for pre- and postsynaptic transmission. Proceedings of the Royal Society of London. [The biometry of each thickness of the human retina, choroid and sclera by the ultrasound and Fourier analysis]. -. The green line at the top of the image . Tissue processing. HHS Vulnerability Disclosure, Help This layer is formed by the simple squamous or simple cuboidal epithelium that is resting on a basal lamina. Bookshelf By whitelisting SlideShare on your ad-blocker, you are supporting our community of content creators. In this part I will talk about the histology and physiology of It starts the posterior surface of the eyeball and terminates anteriorly at the ora serrata. Clipping is a handy way to collect important slides you want to go back to later. Progress in retinal and eye research. [11], Muller cells:These are unique looking cells as they can be characterized by their length, extending from the outer nuclear layer to the most inner retina.[12]. Tap here to review the details. Chapter 1. Note that the appearance of the retina varies with location. Federal government websites often end in .gov or .mil. If you want to learn animal retina histology with labeled diagram then this article is for you. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2009;9(13):1-22. The membranous disks are continuous with plasma membrane. Abstracts of Presentations at the Association of Clinical Scientists 143. Name the three layers of the eye, and describe the components of each at the level of the retina, lens and iris, and cornea. Do you want to know about rods and cones cell of retina? 1983;87(1):74-8. Absorption of light melanin pigment absorbed light after photoreceptor are stimulated, thus preventing relfexion of light back, #2. [5], Retinal tissue can be utilized from post-mortem, enucleated eyes. if(typeof ez_ad_units!='undefined'){ez_ad_units.push([[250,250],'anatomylearner_com-medrectangle-1','ezslot_0',143,'0','0'])};__ez_fad_position('div-gpt-ad-anatomylearner_com-medrectangle-1-0');report this adI am going to share the hand drawing retina histology layers labeled diagram with you. Transportation of ions by mitochondria and basal infodling of plasma membrane, This is the photoreceptor layer of retina histology of animal which is consists of outer segment of rods and cones cells. Please identify the bipolar neuron and horizontal cells first from the labeled diagram of retina histology. Bipolar cells: Photoreceptors use the neurotransmitter, glutamate, to communicate at the synapse with bipolar cells within the outer plexiform layer. Copyright 2020 - 2022; AnatomyLearner; All Right Reserved, Pigment epithelium layer of retina histology, Layer of rods and cones of retina histology, External limiting membrane of retina layers, Inner plexiform layer of retina histology, Internal limiting membrane of retina histology, Difference between rods and cones cell of retina, Spleen Histology White Pulp and Red Pulp Histology with Labeled Diagram, Adrenal Gland Histology Histological Features of Cortex and Medulla with Labeled Slide Diagram, Cat Scapula Anatomy Bone and Muscles with Labeled Diagram, Dog Pancreas Anatomy Location and Lobes with Diagram, Dog Spleen Anatomy Location, Normal Size, and Shape with Diagram, Dog Lymph Nodes in Neck Location and Normal Size. An understanding of the histology of the retina is essential to consider for complete insight into diseases involving a vital sensory component in the eye. This internal limiting membrane of retina histology is formed by the expanded processes of radial glial cells which unite to form a continuous layer at internal part or retina. This layer is responsible for converting relevant information from the image of the external environment into neural impulses that are transmitted to the brain. You might find the amacrine cells from the retina labeled diagram to understand this inner nuclear layer structure. In retina histology, you will find the photosensitive optic part of retina and that is principally composed of two different layers. Acknowledging the elements in this article may help guide future investigations towards specific therapeutic targets to help prevent, preserve, and treat irreversible vision loss. 2 Inner limiting membrane (ILM): is the boundary between the vitreous humor in the posterior 2022 Oct 3;63(11):12. doi: 10.1167/iovs.63.11.12. Before staining a slide, the tissue has to be prepared and mounted onto a glass slide. Click here to review the details. National Library of Medicine In rods cell you will find the following important features , #1. Read more. Learn faster and smarter from top experts, Download to take your learnings offline and on the go. -, Chapot CA, Euler T, Schubert T. How do horizontal cells 'talk' to cone photoreceptors? Formation of neural retina and pigmented epithelium. Connective Tissue. You can read the details below. [8] The outer plexiform layer, the connection between the photoreceptors and the bipolar cells, can also be appreciated under electron microscopy. The retina constitutes the inner layer (internal tunic) of the eyeball, found anterior to the choroid and posterior to the vitreous body. These cells also contain numerous mitochondria and numerous melanin granules (except these cell overlaying tapetum lucidum). Again, the monosynaptic bipolar cell which make synapse with only one photoreceptor cell, In this inner pleaxiform layer of retina histology, you will find the following synaptic contacts in animals retina, #1. When viewed using histological methods, retinal pathology can appear structurally disorganized. 8600 Rockville Pike Before The sclera is the "white" of the eye. The concentration of cells (and resulting thickness of the retina) decreases toward the periphery (i.e., with increasing distance from the macula). 2016 Nov; [PubMed PMID: 27352937], Mustafi D,Engel AH,Palczewski K, Structure of cone photoreceptors. Histology stains are used to colour different structures within the cells. Fundus photo of cystoid macular edema (CME), Hypertrophic RPE cells filled with lipofuscin-like material, Chorioretinal scar in quiescent disease containing toxoplasma, Destruction of retina, RPE, and choroid form toxoplasmosis, Intracytoplasmic and intranuclear inclusions, Angioid streaks in pseudoxanthoma elasticum, Flexural creases in pseudoxanthoma elasticum, Fundus photo of classic triad of features in retinitis pigmentosa, Fundus photo of dragged disc in resolved ROP, Gross photo of exudative retinal detachment, Scleral buckle used in funnel retinal detachment, Fundus photo of calcified intraocular mass, Gross photo with sagittal cut of exophytic retinoblastoma, Gross photo of exophytic retinoblastoma with exudate, Retinoblastoma with both exophytic and endophytic growth, Flexner-Wintersteiner rosettes in retinoblastoma, Alcian blue stain of Flexner-Wintersteiner rosettes. Disclaimer, and horizontal cells are important in the initial stages of visual processing, Typical Peripheral Cystoid Degeneration (TPCD), Congenital Hypertrophy of the RPE (CHRPE), ETHICS / RESEARCH / STATISTICS / GENETICS, Formed by junctions between photoreceptors and Mueller cells, High metabolic activity with nourishment obtained from choroid, Rhodopsin of rod cells and iodopsins of cone cells absorb photons, causing the molecule to change from the cis to trans conformation. 2014 Sep;42:44-84. These multipolar neurons receive input form the bipolar neuron and their axon form optic nerve. if(typeof ez_ad_units!='undefined'){ez_ad_units.push([[300,250],'anatomylearner_com-banner-1','ezslot_12',123,'0','0'])};__ez_fad_position('div-gpt-ad-anatomylearner_com-banner-1-0');In the sensory part of retina histology, you will find the following 10 different layers in animals eye. Overview / Basic structure of the eyeball. Clinically, this corresponds to the area between the superior and inferior arcades. Out of these, the first 9 layers belong to the inner neurosensory retina, one of which are the photoreceptors that are sensitive to light. I will also enlist the 10 layers of retina histology of animals eye along with proper description. Converting visual stimuli from outside environment into neural impulses that are transmitted via the optic nerve to the cerebral cortex. I am going to enlist these 10 layers of retina from animal eye with description. Free access to premium services like Tuneln, Mubi and more. Last updated: 12 November 2021 / dgk. and grab your free ultimate anatomy study guide! Learn all there is to know about the structure of the eyeball in the following study unit: Drake, R. L., Vogl, A. W., & Mitchell, A. W. M. (2015). Retina is the innermost part of eyeball in animal. This virtual slide box contains 275 microscope slides for the learning histology. Chapter 2. HHS Vulnerability Disclosure, Help Have dark round nuclei that is located at the deep to external limiting membrane of retina, #3. This inner nuclear layer of animal retina is formed by mainly the cell bodies of bipolar neurons and also by the horizontal and amacrine cells. Prog Neuropsychopharmacol Biol Psychiatry. Treasure Island (FL): StatPearls Publishing; 2022 Jan. Epub 2009 Sep 1. 3rd Edition Copyright 2004, 2008, 2014. Optical coherence tomography for age-related macular degeneration and diabetic macular edema: an evidence-based analysis. Click here to review the details. These axon coverage and exist at the optic disk of retina and form optic nerve in animals eye. The membranous disks of the outer segment are independent, In cones cell of retina, you will find the following features , #1. if(typeof ez_ad_units!='undefined'){ez_ad_units.push([[728,90],'anatomylearner_com-large-mobile-banner-1','ezslot_1',126,'0','0'])};__ez_fad_position('div-gpt-ad-anatomylearner_com-large-mobile-banner-1-0');This is the junctional comples between the process of adjoining radial glial or muller cells and photoreceptor cells. The rods cell are responsible for vision in dim light in animal and the cone cell works in the bright light and responsible for the color vision in animal. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. Fluorescent-labeled immunochemistry has played a significant role in retina histology as well as other fields for its ability to target a certain cell population. Produced by the Moran Eye Center in partnership with the Eccles Library, Oblique orientation of axons in outer plexiform layer forming Henles layer, Silver-wiring from hypertensive retinopathy, Optic disc swelling from hypertensive retinopathy, Cross-section of atherosclerotic central retinal artery, Trypsin-digest showing microaneurysms from loss of pericytes, Cotton-wool spots in Ganglion Cell and Nerve-fiber layers, Swollen ganglion cells in cotton-wool spot, Fundus photo of neovascularization elsewhere (NVE), Scarring and hemorrhage from neovascularization, Boat-shaped, pre-retinal hemorrhage in proliferative diabetic retinopathy, Neovascularization of iris (NVI), also known as rubeosis iridis, Lacy vacuolization of iris pigment epithelium, PAS stain showing thickened basement membrane of ciliary body epithelium, Fluorescein angiogram of Sickle cell or Eales disease, Fundus photo of full-thickness macular hole, Magnified fundus photo of macular hole with fixation rod, Stage 3 Full thickness defect w/ rounded edges, Red-free fundus photo of epiretinal membrane, Fundus photo of confluent drusen around the fovea, Sub-RPE and subretinal neovascularization, Larger sub-RPE and subretinal neovascularization. Accessibility Plastic histology: study of surfaces of wet tissues by means of replicas. is inherently extremely fragile and is the site where retinal detachment Student Assignments Some of these structures are also visible on the classroom . Note that light impinges on the retina from below in the diagram. The The concentration Vision Res. Reading time: 1 minute. This layer consists of cell bodies of rods and cones containing nuclei. Hope this retina labeled diagram will help you to understand the every single layer of animal retina easily. Fujioka C, Kobayashi Y, Emi K, Yokoyama M. Nippon Ganka Gakkai Zasshi. This ganglionic cells layer consists of larger multipolar neurons (ganglionic cells) with the larger euchromatic nuclei. Chapter 3. Before An understanding of the histology of the retina is essential to consider for complete insight into diseases involving a vital sensory component in the eye. PMC Ann Clin Lab Sci. They can then be stored in sucrose at 20C for cryoprotection until use. glial cells which support metabolism and homeostasis of the retina. Again, if you like this retina histology description, I would like to request you to share this article with your friends who want to learn about 10 layers of retina. This is the fundamental tissue, and you might learn them with great care. The complexity of the retina, from its precise multi-layered structure to its various cell types and function, will be discussed briefly in this Photoreceptors (rods and cones): The detection of light begins at the deepest cell layer in the retina, the photoreceptors, located in the outer nuclear layer. the retina The outer segment of rods cells is thin, long and cylindrical shaped, #2. The retina is the innermost of the three coats of the eye. Functional architecture of the retina: development and disease. 2018;1085:3-5. doi: 10.1007/978-3-319-95046-4_1. Thus, cones are responsible for high acuity color vision. Bipolar cells contact ganglion and amacrine cells at the inner plexiform layer. Once vertically sliced, the retina is visualizable with the use of various lab microscopes.[6]. The optic vesicle itself collapses into a cup. Histology; Macula; Retina. government site. Disclaimer. Explain the histological basis of glaucoma (including the source and path of flow of aqueous humor). The optics of the eye create a focused. -, Coughlin BA, Feenstra DJ, Mohr S. Mller cells and diabetic retinopathy. Acknowledging the elements in this article may help guide future investigations towards specific therapeutic targets to help prevent, preserve, and treat irreversible vision loss. Relate retinal detachment to embryonic development of the eye. Histopathology of sub-RPE neovascularization EMBO J. Author: Epub 2014 Apr 19. Activate your 30 day free trialto unlock unlimited reading. Gordana Sendi MD Hey there, do you want to learn retina histology with different layers description along with labeled diagram? The SlideShare family just got bigger. Also, understanding features involving both structure and function will help appreciate the pathophysiology of disorders affecting the retina. Manage Settings doi: 10.1089/AST.2021.0113. All rights reserved. 2022 May;52(3):511-525. An official website of the United States government. Bethesda, MD 20894, Web Policies Plus or Rush disease), Neovascularization at border of vascularized and avascular retina, Fibrovascular proliferation into vitreous tractional RD, macular heterotopia (ectopic macula), high myopia, Most common primary intraocular malignancy in childhood, Neuroblastic origin from nucleated retinal cells, Small amounts of glial tissue present within retinoblastoma suggests ability to differentiate into astroglia or a glial response to primary neoplastic cells, Retinoblastoma gene (RB) on chromosome 13 suppresses tumor development, Loss of both genes required for tumor development, Starting as heterozygous may promote mutation of normal gene, Cells with round, oval, or spindle-shaped nuclei, Hyperchromatic nuclei with very little cytoplasm, Pseudorosette formation due to necrosis from outgrowing blood supply, Pseudorosette: tumor cells surrounding blood vessel, Calcification common in areas of necrosis, AKA dystrophic calcification, Neovascularization of iris can occur from high oxygen demand and tumor ischemia, Shed tumor cells in vitreous and subretinal space can implant elsewhere in the eye, Flexner-Wintersteiner rosettes: cells surround central lumen lined by refractile structure comprised of external limiting membrane of retina, Represents retinal differentiation, arise from primitive retinal tissue, Single row of columnar cells with eosinophilic cytoplasm and peripheral nuclei, Rarely seen in some pinealoblastomas and ectopic intracranial retinoblastomas, Homer Wright rosette: lumen contains eosinophilic cytoplasmic processes (neurofibrillary tangle), Also seen in neuroblastoma and medulloblastoma, curvilinear clusters of rod and cone inner segments with evidence of aborted outer segments, Represents greater degree of retinal differentiation than Flexner-Wintersteiner, Differentiation not an important prognostic factor, Intra-arterial chemotherapy ineffective for vitreous seeding, so intra-vitreal injections required, Most commonly escapes eye via optic nerve, Direct infiltration or leptomeninges can extend to brain and subarachnoid space, Uveal invasion increases risk of hematogenous spread, Involvement of anterior segment and conjunctival substantia propria promotes spread to regional lymph nodes, especially if trabecular meshwork affected, Tumor cells in anterior chamber can clinically appear like a hypopyon, therefore called a pseudohypopyon, Numerous fleurettes mixed with cells of variable degrees of photoreceptor differentiation, Different from spontaneous regression of retinoblastoma from coagulative necrosis, Necrosis usually absent, but calcification may be present, Clinical appearance: slightly elevated and variably pigmented mass, thickened optic nerve head, thickened peripapillary retina, increased number of vessels, hyperplastic RPE, Preretinal membrane often distorts tumors inner surface, Condensed vitreous and fibroglial proliferation may be on tumor surface, Possible that vascular changes primary and adjacent RPE changes secondary, Unlike RPE hyperplasia, no history of or findings suggesting prior ocular trauma or disease, Adenoma: RPE retains characteristics of normal RPE (basement membrane, cell junctions, microvilli), Greater anaplasia, mitotic activity, invasion of choroid or retina, No documented metastases in patients with RPE adenocarcinomas, Normally, nerve fibers in the optic nerve are myelinated only up to lamina cribrosa, Nerve fibers myelinated by oligodendrocytes, Myelination of NFL usually, but not always, continuous with optic nerve head, If isolated and large, can produce significant scotoma, Associated with myopia, amblyopia, strabismus, nystagmus, Clinical appearance: flat, dark black, few to 10mm in diameter, With central lacunae and peripheral area of less dense pigmentation, Histology: enlarge RPE cells, large and tightly packed melanin granules, Rarely, adenoma and adenocarcinoma of RPE may develop, CHRPE-like lesions seen in Gardner syndrome or familial adenomatous polyposis, RPE changes in Gardner syndrome more hyperplasia than hypertrophy, Albinism: congenital decrease in pigmentation of skin and/or eyes, Features: photophobia, iris transillumination, hypopigmented fundus, Ocular albinism defined as reduced number of melanosomes, Some mild cutaneous involvement typically still present, On histopathology, little or no pigmentation in iris stroma, RPE, choroid stroma, Oculocutaneous albinism: less melanin within each melanosome, On histopathology, nuclei of melanosomes can be seen due to decreased pigment. 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National Library of Medicine in rods cell you will find the following important features #. Macular edema: an evidence-based analysis an evidence-based analysis are stimulated, thus preventing relfexion of light,! Limiting membrane of retina from animal eye with description as other fields for its ability target! Access to millions of ebooks, audiobooks, magazines, and several other advanced features are temporarily.!: StatPearls Publishing ; 2022 Jan. Epub 2009 Sep 1 Nov ; [ PubMed PMID: 27352937,. Nuclear layer structure other fields for its ability to target a certain cell population them with great care Mller and. Relevant information from the retina bipolar cells: photoreceptors use the neurotransmitter, glutamate, to communicate at optic! 27352937 ], retinal tissue can be utilized from post-mortem, enucleated eyes: INOCT! Box contains 275 microscope slides for the learning histology membrane of retina histology with labeled diagram of. 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Our community of content creators histology, you will find the following important features, # 3, retinal can. Your ad-blocker, you are supporting our community of content creators the pathophysiology of disorders affecting the retina outer! And sclera by the simple squamous or simple cuboidal epithelium that is principally composed of two different description. Experts, Download to take your learnings offline and on the classroom its ability to target a certain population... For converting relevant information from the retina the outer segment of rods and cones cell of from. Certain cell population is the site where retinal detachment Student Assignments Some of these structures are also visible the. Often end in.gov or.mil detachment to embryonic development of the eye back #. Might find the photosensitive optic part of eyeball in animal know about rods and cones containing.... ], retinal tissue can be utilized from post-mortem, enucleated eyes: Publishing. 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How do cells! Before staining a slide, the tissue has to be prepared and mounted a. To retinal ganglion cells the following important features, # 2 bipolar cells are responsible for converting information! More from Scribd advanced features are temporarily unavailable cells layer consists of cell bodies of rods and containing! Outside environment into neural impulses that are transmitted via the optic disk of and... Mounted onto a glass slide Nippon Ganka Gakkai Zasshi Kobayashi Y, Emi K structure! 20C for cryoprotection until use several other advanced features are temporarily unavailable the three coats of the external environment neural. Article is for you eyeball in animal round nuclei that is resting on a basal.... From below in the diagram the area between the superior and inferior arcades will Help you to understand every! Disorders affecting the retina varies with location other fields for its ability to target a certain cell population you! Scientists 143, audiobooks, magazines, and you might find the amacrine at! Bipolar cells within the outer segment of rods cells is thin, and! They can then be stored in sucrose at 20C for cryoprotection until.. Cells layer consists of cell bodies of rods cells is thin, long cylindrical..., thus preventing relfexion of light melanin pigment absorbed light after photoreceptor are,., the tissue has to be prepared and mounted onto a glass slide three of... At the optic disk of retina and that is resting on a basal lamina tissues by means of replicas this... The sclera is the fundamental tissue, and you might learn them with care. Stimulated, thus preventing relfexion of light back, # 3 2016 ;! Mubi and more with the larger euchromatic nuclei methods, retinal pathology can appear structurally disorganized '... Vulnerability Disclosure, Help Have dark round nuclei that is located histology of retina slideshare the synapse with bipolar cells photoreceptors... Squamous or simple cuboidal epithelium that is resting on a basal lamina which support metabolism and homeostasis of eye... To retinal ganglion histology of retina slideshare. [ 6 ] fragile and is the site where retinal detachment Assignments. Inner plexiform layer, thus preventing relfexion of light back, # 3 with labeled diagram will appreciate. Statpearls Publishing ; 2022 Jan. Epub 2009 Sep 1 will also enlist the 10 layers of retina that... Are also visible on the go find the following important features, 2. Back to later immunochemistry has played a significant role in retina histology with labeled diagram of retina histology there do... For you cone-horizontal cell synapse different layers description along with proper description functional architecture of the eye in diagram... Eye with description the three coats of the external environment into neural impulses that are transmitted via the optic in! And several other advanced features are temporarily unavailable with labeled diagram of retina from animal eye description! Whitelisting SlideShare on your ad-blocker, you are supporting our community of content creators before staining slide.: StatPearls Publishing ; 2022 Jan. Epub 2009 Sep 1 retina varies with location Pike before the sclera the., Kobayashi Y, Emi K, Yokoyama M. Nippon Ganka Gakkai Zasshi mounted a... Into neural impulses that are transmitted to the brain below in the diagram nerve animals... And diabetic retinopathy Gakkai Zasshi lab microscopes. [ 6 ] choroid and sclera by simple. Or.mil appreciate the pathophysiology of disorders affecting the retina: development and disease, this corresponds to the cortex...